Daniela Delneri

About

Daniela is currently a Full Professor at the University of Manchester in the area of Evolutionary and Functional Genomics and became Associate Dean for Research and Innovation in Biology/Biotech in November 2023. In previous years she was the Research Director of the “Computational and Evolutionary Biology” Group in the Faculty of Life Sciences at the University of Manchester (2013-2016). As undergraduate, she studied Biological Sciences and graduated with 110/110 cum Laude (1991) from the University of Trieste, Italy, with a thesis in the field of infection and medical microbiology. She was awarded the PhD in Biochemistry in 1997 (University of Trieste & ICGEB, Area Science Park, Trieste), where she focussed on biodegradation pathways of lignocellulose derivatives in bacteria and yeast. She was able to secure an EC TMR Senior Fellow at UMIST (1997-1999) studying the importance of genetic redundancy on evolutionary processes. She started her independent career in 2004 as NERC Advanced Fellow at the University of Manchester, UK. With twenty-five years’ worth of experience in yeast genetics and molecular biology, she focusses on understanding the interplay between genes and environment, including plasticity of mutations in protein coding genes and non-coding RNAs elements, the impact of chromosomal rearrangements on reproductive isolation and fitness, and the evolution of genomes in hybrid species including biotechnological aspects. She collaborates with several industries in strain development via hybridisation and trait selection in particularly relevant to the food and beverage sector and to the biorefinery processes.

Work

The University of Manchester

United Kingdom of Great Britain and Northern Ireland

University of Manchester
|

Professor of Evolutionary Genomics

United Kingdom of Great Britain and Northern Ireland

Education

University of Trieste
Italy

PhD Biochemistry

University of Trieste
Italy

Laurea in Biologia (BSc Honour Biological Sciences)

Publications

Silica hydrogels as a carbon-free solid media for the culture of diverse organisms

Published by

FEMS microbes

Summary

journal-article

Functional analysis of the Aspergillus fumigatus kinome identifies a druggable DYRK kinase that regulates septal plugging

Published by

Nature Communications

Summary

journal-article

Effect of Hanseniaspora vineae and Saccharomyces cerevisiae co-fermentations on aroma compound production in beer.

Published by

Food microbiology

Summary

journal-article

Development of a genome-scale metabolic model for the lager hybrid yeast S. pastorianus to understand the evolution of metabolic pathways in industrial settings

Published by

mSystems

Summary

journal-article

Development of a genome-scale metabolic model for the lager hybrid yeast <i>S. pastorianus</i> to understand the evolution of metabolic pathways in industrial settings.

Published by

mSystems

Summary

journal-article

Functional analysis of the Aspergillus fumigatus kinome identifies a druggable DYRK kinase that regulates septal plugging.

Published by

Nature communications

Summary

journal-article

Minimisation of metabolic networks defines a new functional class of genes.

Published by

Nature communications

Summary

journal-article

High quality de novo genome assembly of the non-conventional yeast Kazachstania bulderi describes a potential low pH production host for biorefineries.

Published by

Communications biology

Summary

journal-article

High quality de novo genome assembly of the non-conventional yeast Kazachstania bulderi describes a potential low pH production host for biorefineries

Published by

Communications Biology

Summary

journal-article

Functional analysis of the Aspergillus fumigatus kinome reveals a DYRK kinase involved in septal plugging is a novel antifungal drug target

Published by

Research Square

Summary

journal-article

Development of a genome scale metabolic model for the lager hybrid yeastS. pastorianusto understand evolution of metabolic pathways in industrial settings

Summary

working-paper

Telomere-to-telomere genome sequence of the model mould pathogen Aspergillus fumigatus.

Published by

Nature communications

Summary

journal-article

Mitonuclear interplay in yeast: from speciation to phenotypic adaptation.

Published by

Current opinion in genetics & development

Summary

journal-article

Eisosome disruption by noncoding RNA deletion increases protein secretion in yeast.

Published by

PNAS nexus

Summary

journal-article

Telomere-to-telomere genome sequence of the model mould pathogen Aspergillus fumigatus

Published by

Nature Communications

Summary

journal-article

Quantitative Characterisation of Low Abundant Yeast Mitochondrial Proteins Reveals Compensation for Haplo-Insufficiency in Different Environments

Published by

International Journal of Molecular Sciences

Summary

journal-article

Volatile aroma compound production is affected by growth rate in S. cerevisiae

Published by

Applied and Environmental Microbiology|A E M

Summary

journal-article

Volatile Aroma Compound Production Is Affected by Growth Rate in S. cerevisiae.

Published by

Applied and environmental microbiology

Summary

journal-article

Eisosome disruption by non-coding RNA deletion increases protein secretion in yeast

Published by

PNAS Nexus

Summary

journal-article

Transcriptional Profile of the Industrial Hybrid Saccharomyces pastorianus Reveals Temperature-Dependent Allele Expression Bias and Preferential Orthologous Protein Assemblies

Published by

Molecular Biology and Evolution

Summary

journal-article

Restoring fertility in yeast hybrids: Breeding and quantitative genetics of beneficial traits

Published by

Proceedings of the National Academy of Sciences

Summary

journal-article

Functional and transcriptional profiling of non-coding RNAs in yeast reveal context-dependent phenotypes and in trans effects on the protein regulatory network

Published by

PLoS Genetics

Summary

journal-article

Genomic Adaptation of Saccharomyces Species to Industrial Environments

Published by

Frontiers in Genetics

Summary

journal-article

HybridMine

Published by

Microorganisms

Summary

journal-article

HybridMine: A Pipeline for Allele Inheritance and Gene Copy Number Prediction in Hybrid Genomes and Its Application to Industrial Yeasts

Published by

Microorganisms

Summary

journal-article

An update on the diversity, ecology and biogeography of the Saccharomyces genus

Published by

FEMS Yeast Research

Summary

journal-article

Plasticity of Mitochondrial DNA Inheritance and its Impact on Nuclear Gene Transcription in Yeast Hybrids

Published by

Microorganisms

Summary

journal-article

Plasticity of Mitochondrial DNA Inheritance and Its Impact on Nuclear Gene Transcription in Yeast Hybrids

Published by

Microorganisms

Summary

journal-article

High throughput gene replacement in Aspergillus fumigatus

Published by

Current Protocols in Microbiology

Summary

journal-article

Fast and reliable PCR amplification from Aspergillus fumigatus spore suspension without traditional DNA extraction

Published by

Current Protocols in Microbiology

Summary

journal-article

Targeted metagenomics approach to capture the biodiversity of Saccharomyces genus in wild environments

Published by

Environmental Microbiology Reports

Summary

journal-article

Large-scale profiling of noncoding RNA function in yeast

Published by

PL o S Genetics

Summary

journal-article

HISTORY OF GENOME EDITING IN YEAST

Published by

Yeast

Summary

journal-article

Whole genome sequencing, de novo assembly and phenotypic profiling for the new budding yeast species Saccharomyces jurei

Published by

G3: Genes, Genomes, Genetics (Bethesda)

Summary

journal-article

A resource for functional profiling of noncoding RNA in the yeast Saccharomyces cerevisiae

Published by

RNA

Summary

journal-article

Rapid functional and evolutionary changes follow gene duplication in yeast

Published by

Proceedings of the Royal Society B: Biological Sciences

Summary

journal-article

Saccharomyces jureii sp. nov., Isolation and Genetic Identification of a Novel Yeast Species from Quercus robur.

Published by

International Journal of Systematic and Evolutionary Microbiology

Summary

journal-article

Novel Intronic RNA Structures Contribute to Maintenance of Phenotype in Saccharomyces cerevisiae

Published by

Genetics

Summary

journal-article

Induced expression of defence-related genes in barley is specific to aphid genotype

Published by

Biological Journal of the Linnean Society

Summary

journal-article

Induced expression of defence‐related genes in barley is specific to aphid genotype

Summary

other

Widespread Impact of Chromosomal Inversions on Gene Expression Uncovers Robustness via Phenotypic Buffering.

Summary

journal-article

Widespread Impact of Chromosomal Inversions on Gene Expression Uncovers Robustness via Phenotypic Buffering

Published by

Molecular Biology and Evolution

Summary

journal-article

Non-coding RNAs and disease: the classical ncRNAs make a comeback

Published by

Biochemical Society Transactions

Summary

journal-article

Non-coding RNAs and disease: the classical ncRNAs make a comeback.

Summary

journal-article

Novel Intronic RNA Structures Contribute to Maintenance of Phenotype in Saccharomyces cerevisiae.

Summary

journal-article

Sequencing and characterisation of rearrangements in three S. pastorianus strains reveals the presence of chimeric genes and gives evidence of breakpoint reuse

Published by

PLoS ONE

Summary

journal-article

Osteoblastic cell secretome: a novel role for progranulin during risedronate treatment.

Summary

journal-article

Limb Displays of Male Saitis barbipes (Simon, 1868) (Araneae: Salticidae)

Published by

Arachnology

Summary

journal-article

Environmental systems biology of cold-tolerant phenotype in Saccharomyces species adapted to grow at different temperatures

Published by

Molecular ecology

Summary

journal-article

Intron evolution in Saccharomycetaceae

Published by

Genome biology and evolution

Summary

journal-article

Intron evolution in Saccharomycetaceae.

Summary

journal-article

Environmental systems biology of cold-tolerant phenotype in Saccharomyces species adapted to grow at different temperatures.

Summary

journal-article

Sequencing and characterisation of rearrangements in three S. pastorianus strains reveals the presence of chimeric genes and gives evidence of breakpoint reuse.

Summary

journal-article

Chimeric Protein Complexes in Hybrid Species Generate Novel Phenotypes

Published by

PL o S Genetics

Summary

journal-article

Chimeric protein complexes in hybrid species generate novel phenotypes.

Summary

journal-article

Characterization and prediction of haploinsufficiency using systems-level gene properties in yeast.

Summary

journal-article

Osteoblastic cell secretome: A novel role for progranulin during risedronate treatment.

Published by

Bone

Summary

journal-article

Characterization and prediction of haploinsufficiency using systems-level gene properties in yeast

Published by

G3: Genes, Genomes, Genetics

Summary

journal-article

Non-coding RNAs in Saccharomyces cerevisiae: what is the function?

Summary

journal-article

Impact of chromosomal inversions on the yeast DAL cluster

Published by

PLoS ONE

Summary

journal-article

Impact of chromosomal inversions on the yeast DAL cluster.

Summary

journal-article

Non-coding RNAs in Saccharomyces cerevisiae: What is the function?

Published by

Biochemical Society Transactions

Summary

journal-article

Genome-wide analysis of longevity in nutrient-deprived Saccharomyces cerevisiae reveals importance of recycling in maintaining cell viability.

Published by

Environmental microbiology

Summary

journal-article

Genome-wide analysis of longevity in nutrient-deprived Saccharomyces cerevisiae reveals importance of recycling in maintaining cell viability.

Summary

journal-article

The yeast factory.

Summary

journal-article

Knock-in reconstitution studies reveal an unexpected role of Cys-65 in regulating APE1/Ref-1 subcellular trafficking and function

Published by

Molecular Biology of the Cell

Summary

journal-article

Competition experiments coupled with high-throughput analyses for functional genomics studies in yeast

Published by

Yeast Systems Biology

Summary

book-chapter

Competition experiments coupled with high-throughput analyses for functional genomics studies in yeast.

Summary

journal-article

Knock-in reconstitution studies reveal an unexpected role of Cys-65 in regulating APE1/Ref-1 subcellular trafficking and function.

Summary

journal-article

Genome-wide analysis of yeast stress survival and tolerance acquisition to analyze the central trade-off between growth rate and cellular robustness

Published by

Molecular Biology of the Cell

Summary

journal-article

Genome-wide analysis of yeast stress survival and tolerance acquisition to analyze the central trade-off between growth rate and cellular robustness.

Summary

journal-article

Fusel alcohols regulate translation initiation by inhibiting eIF2B to reduce ternary complex in a mechanism that may involve altering the integrity and dynamics of the eIF2B body

Published by

Molecular Biology of the Cell

Summary

journal-article

Fusel alcohols regulate translation initiation by inhibiting eIF2B to reduce ternary complex in a mechanism that may involve altering the integrity and dynamics of the eIF2B body.

Summary

journal-article

Correction: Evolutionary Systems Biology of Amino Acid Biosynthetic Cost in Yeast.

Summary

journal-article

Evolutionary systems biology of amino acid biosynthetic cost in yeast

Published by

PLoS ONE

Summary

journal-article

Gene duplication and environmental adaptation within yeast populations.

Summary

journal-article

Gene duplication and environmental adaptation within yeast populations

Published by

Genome biology and evolution

Summary

journal-article

Evolutionary systems biology of amino acid biosynthetic cost in yeast.

Summary

journal-article

Barcode technology in yeast: Application to pharmacogenomics

Published by

FEMS Yeast Research

Summary

journal-article

Barcode technology in yeast: application to pharmacogenomics.

Summary

journal-article

New generation of loxP-mutated deletion cassettes for the genetic manipulation of yeast natural isolates

Published by

Yeast

Summary

journal-article

New generation of loxP-mutated deletion cassettes for the genetic manipulation of yeast natural isolates.

Summary

journal-article

Genome-Wide analysis and proteomic studies reveal APE1/Ref-1 multifunctional role in mammalian cells

Published by

Proteomics

Summary

journal-article

Identification of secondary targets of N-containing bisphosphonates in mammalian cells via parallel competition analysis of the barcoded yeast deletion collection

Published by

Genome biology

Summary

journal-article

Identification of secondary targets of N-containing bisphosphonates in mammalian cells via parallel competition analysis of the barcoded yeast deletion collection.

Summary

journal-article

Transcriptome and proteome analysis of osteocytes treated with nitrogen-containing bisphosphonates

Published by

Journal of Proteome Research

Summary

journal-article

Transcriptome and proteome analysis of osteocytes treated with nitrogen-containing bisphosphonates.

Summary

journal-article

Genome-wide analysis and proteomic studies reveal APE1/Ref-1 multifunctional role in mammalian cells.

Summary

journal-article

Probing (macro)molecular transport through cell walls

Published by

Faraday Discussions

Summary

journal-article

Identification and characterization of high-flux-control genes of yeast through competition analyses in continuous cultures

Published by

Nature Genetics

Summary

journal-article

Identification and characterization of high-flux-control genes of yeast through competition analyses in continuous cultures.

Summary

journal-article

Probing (macro)molecular transport through cell walls.

Summary

journal-article

Cellular processes and pathways that protect Saccharomyces cerevisiae cells against the plasma membrane-perturbing compound chitosan.

Summary

journal-article

Application of the comprehensive set of heterozygous yeast deletion mutants to elucidate the molecular basis of cellular chromium toxicity

Published by

Genome biology

Summary

journal-article

Application of the comprehensive set of heterozygous yeast deletion mutants to elucidate the molecular basis of cellular chromium toxicity.

Summary

journal-article

Cellular processes and pathways that protect Saccharomyces cerevisiae cells against the plasma membrane-perturbing compound chitosan

Published by

Eukaryotic Cell

Summary

journal-article

Plasticity of genetic interactions in metabolic networks of yeast

Published by

Proceedings of the National Academy of Sciences of the United States of America

Summary

journal-article

Plasticity of genetic interactions in metabolic networks of yeast.

Summary

journal-article

Development of novel guanidino-labelling derivatisation (GLaD) reagents for liquid chromatography/matrix-assisted laser desorption/ionisation analysis

Published by

Rapid communications in mass spectrometry : RCM

Summary

journal-article

Development of novel guanidino-labelling derivatisation (GLaD) reagents for liquid chromatography/matrix-assisted laser desorption/ionisation analysis.

Summary

journal-article

Functional Analysis, Genome Redundancy and Speciation in Yeast

Summary

book

Effects of reciprocal chromosomal translocations on the fitness of Saccharomyces cerevisiae

Published by

EMBO reports

Summary

journal-article

Effects of reciprocal chromosomal translocations on the fitness of Saccharomyces cerevisiae.

Summary

journal-article

The use of yeast mutant collections in genome profiling and large-scale functional analysis

Published by

Current Genomics

Summary

journal-article

GIMS: an integrated data storage and analysis environment for genomic and functional data.

Summary

journal-article

GIMS: An integrated data storage and analysis environment for genomic and functional data

Published by

Yeast

Summary

journal-article

Engineering evolution to study speciation in yeasts

Published by

Nature

Summary

journal-article

Engineering evolution to study speciation in yeasts.

Summary

journal-article

Tools for the study of genome rearrangements in laboratory and industrial yeast strains

Published by

Yeast

Summary

journal-article

Tools for the study of genome rearrangements in laboratory and industrial yeast strains.

Summary

journal-article

Towards a truly integrative biology through the functional genomics of yeast

Published by

Current Opinion in Biotechnology

Summary

journal-article

Towards a truly integrative biology through the functional genomics of yeast.

Summary

journal-article

Exploring redundancy in the yeast genome: An improved strategy for use of the cre-loxP system

Published by

Gene

Summary

journal-article

Exploring redundancy in the yeast genome: an improved strategy for use of the cre-loxP system.

Summary

journal-article

Analysis of the seven-member AAD gene set demonstrates that genetic redundancy in yeast may be more apparent than real

Published by

Genetics

Summary

journal-article

Analysis of the seven-member AAD gene set demonstrates that genetic redundancy in yeast may be more apparent than real.

Summary

journal-article

Disruption of seven hypothetical aryl alcohol dehydrogenase genes from Saccharomyces cerevisiae and construction of a multiple knock-out strain

Published by

Yeast

Summary

journal-article

Disruption of seven hypothetical aryl alcohol dehydrogenase genes from Saccharomyces cerevisiae and construction of a multiple knock-out strain.

Summary

journal-article

Characterization of microbial cellulose from a high-producing mutagenized Acetobacter pasteurianus strain

Published by

Biochimica et Biophysica Acta - General Subjects

Summary

journal-article

Characterization of microbial cellulose from a high-producing mutagenized Acetobacter pasteurianus strain.

Summary

journal-article

The nucleotide sequence of Saccharomyces cerevisiae chromosome VII

Published by

Nature

Summary

journal-article

The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.

Summary

journal-article

Sequencing of a 40.5 kb fragment located on the left arm of chromosome VII from Saccharomyces cerevisiae

Published by

Yeast

Summary

journal-article

Sequencing of a 40.5 kb fragment located on the left arm of chromosome VII from Saccharomyces cerevisiae.

Summary

journal-article

Degradation of trans-ferulic and p-coumaric acid by Acinetobacter calcoaceticus DSM 586

Published by

Biochimica et Biophysica Acta - General Subjects

Summary

journal-article

Degradation of trans-ferulic and p-coumaric acid by Acinetobacter calcoaceticus DSM 586.

Summary

journal-article

Immunodominant antigens recognized by the human immune response to infection by organisms of the species Leptospira interrogans serogroup Australis.

Summary

journal-article

Immunodominant antigens recognized by the human immune response to infection by organisms of the species Leptospira interrogans serogroup Australis

Published by

FEMS microbiology letters

Summary

journal-article